Toxicokinetics and Tissue Distribution of Deltamethrin in Adult Sprague–Dawley Rats
نویسندگان
چکیده
منابع مشابه
Toxicokinetics and tissue distribution of deltamethrin in adult Sprague-Dawley rats.
The objectives of this study were twofold: (1) to characterize the toxicokinetics and dose-dependent systemic/tissue distribution of deltamethrin (DLM) over a range of doses in adult Sprague-Dawley (S-D) rats; (2) to provide comprehensive time course blood and tissue data for development of a physiologically based toxicokinetic (PBTK) model for DLM. DLM is one of the more neurotoxic members of ...
متن کاملStereoselective toxicokinetics and tissue distribution of ethofumesate in rabbits.
The stereoselective toxicokinetics of ethofumesate enantiomers following a single intravenous (i.v.) administration at doses of 30 mg/kg were investigated in rabbits. Plasma concentrations of (+)- and (-)-ethofumesate were analyzed by a validated chiral HPLC method that involved extraction of plasma with organic solvent followed by separation on a cellulose-Tris-(3,5-dimethylphenylcarbamate)-ba...
متن کاملcoordination of protective schemes in distribution and subtransmission systems including distributed generation
نصب منابع پراکنده در سیستم های توزیع و فوق توزیع علاوه بر مزیت های فراوان، مشکلاتی را هم به همراه دارد. یکی از این مشکلات تأثیر این منابع روی اندازه جریان های اتصال کوتاه است. به طور معمول از حفاظت های مبتنی بر اصل جریان زیاد در سیستم های توزیع و فوق توزیع استفاده می شود. از مهمترین طرح های حفاظتی استفاده شده در فیدرهای توزیع، حفاظت فیوز- ریکلوزر است. همچنین از طرح های حفاظتی جریان زیاد جهتی در...
Formulation-dependent toxicokinetics explains differences in the GI absorption, bioavailability and acute neurotoxicity of deltamethrin in rats.
The acute neurotoxicity of pyrethroid insecticides varies markedly with the dosage vehicle employed. The objective of the present study was to assess the influence of two common vehicles on the bioavailability and toxicokinetics (TK) of a representative pyrethroid insecticide, deltamethrin (DLM), to determine whether the vehicles influence toxic potency by modifying the chemical's TK. Adult, ma...
متن کاملEffect of chlorpyrifos on sperm characteristics and testicular tissue changes in adult male rats
Chlorpyrifos (CPF) is a broad spectrum organophosphate pesticide used for agricultural health purposes. Its principal mechanism of toxicity is the inhibition of acetylcholinesterase. The purpose of present study was to investigate the effects of CPF on testicular tissue and sperm parameters in male rats. Thirty-two healthy male rats were divided into two groups: a CPF-exposed group and a contro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2007
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfm277